Lopez Tonight, a late-night television talk show on TBS, also ran for two seasons. The half hour single camera serialized comedy aired for two seasons. Produced by Lopez, the series explored how he struggled between his two worlds and crises that are often of his own making. In 2004, he was nominated for a GRAMMY in the same category for his CD Team Leader. He released his third standup CD, El Mas Chingon, in 2006, which also earned Lopez a GRAMMY nomination in the category of Best Comedy Album. His acclaimed comedy concert, Why You Crying?, debuted on Showtime in 2004. Lopez also performed as part of HBO and TBS's Comic Relief 2006. Lopez has been featured in four HBO specials, The Wall in August 2017, It’s Not Me, It’s You in 2012, GRAMMY nominated Best Comedy Album Tall, Dark and Chicano in 2009, and America's Mexican in 2007. The comedians also debuted their BET scripted comedy series based on the tour. He also completed his tour for The Comedy Get Down, along with Eddie Griffin, D.L. Last year Lopez was on tour nationwide for his stand-up comedy The Wall World.

Lopez can be seen in his Netflix original comedy special We’ll Do It For Half which premiered globally over the summer.

George Lopez’s multi-faceted career encompasses television, film, standup comedy, and late-night television. George Lopez: Alllriiiighhttt! - Live at AVA Amphitheater

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